Human XPO1(Exportin 1) ELISA Kit

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Exportin 1 (XPO1) in Tissue homogenates, cell lysates and other biological fluids.

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Exportin 1 (XPO1) in Tissue homogenates, cell lysates and other biological fluids.

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Exportin 1 (XPO1) in Tissue homogenates, cell lysates and other biological fluids.

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Exportin 1 (XPO1) in Tissue homogenates, cell lysates and other biological fluids.

Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Exportin 1 (XPO1) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Description: Recombinant Human Exportin 1 expressed in: E.coli

Description: A sandwich ELISA kit for detection of Exportin 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Description: Quantitative sandwich ELISA for measuring Human Exportin-1 (XPO1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Description: Quantitative sandwich ELISA for measuring Human Exportin-1 (XPO1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Description: Quantitative sandwich ELISA for measuring Human Exportin-1 (XPO1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Description: A Rabbit polyclonal antibody against Human, Pig Exportin 1 (XPO1)

Description: A Rabbit polyclonal antibody against Human, Pig Exportin 1 (XPO1). This antibody is labeled with APC.

Description: A Rabbit polyclonal antibody against Human, Pig Exportin 1 (XPO1). This antibody is labeled with Biotin.

Description: A Rabbit polyclonal antibody against Human, Pig Exportin 1 (XPO1). This antibody is labeled with Cy3.

Description: A Rabbit polyclonal antibody against Human, Pig Exportin 1 (XPO1). This antibody is labeled with FITC.

Description: A Rabbit polyclonal antibody against Human, Pig Exportin 1 (XPO1). This antibody is labeled with HRP.

Description: A Rabbit polyclonal antibody against Human, Pig Exportin 1 (XPO1). This antibody is labeled with PE.

Description: A Rabbit polyclonal antibody against Human, Pig Exportin 1 (XPO1). This antibody is labeled with APC-Cy7.

Description: Description of target: Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.6 Publications <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.9"CRM1 is an export receptor for leucine-rich nuclear export signals."_x005F_x005F_x000D_Fornerod M., Ohno M., Yoshida M., Mattaj I.W._x005F_x005F_x000D_Cell 90:1051-1060(1997) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN PROTEIN NUCLEAR EXPORT, IDENTIFICATION IN A NUCLEAR EXPORT COMPLEX WITH RAN.Ref.10"Evidence for a role of CRM1 in signal-mediated nuclear protein export."_x005F_x005F_x000D_Ossareh-Nazari B., Bachelerie F., Dargemont C._x005F_x005F_x000D_Science 278:141-144(1997) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN PROTEIN NUCLEAR EXPORT.Ref.11"The specificity of the CRM1-Rev nuclear export signal interaction is mediated by RanGTP."_x005F_x005F_x000D_Askjaer P., Jensen T.H., Nilsson J., Englmeier L., Kjems J._x005F_x005F_x000D_J. Biol. Chem. 273:33414-33422(1998) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN HIV-1 REV EXPORT, IDENTIFICATION IN A COMPLEX WITH HIV-1 REV; HIV-1 REV RESPONSE ELEMENT AND RAN, INTERACTION WITH HIV-1 REV.Ref.23"A multifunctional domain in human CRM1 (exportin 1) mediates RanBP3 binding and multimerization of human T-cell leukemia virus type 1 Rex protein."_x005F_x005F_x000D_Hakata Y., Yamada M., Shida H._x005F_x005F_x000D_Mol. Cell. Biol. 23:8751-8761(2003) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN HTLV-1 REX EXPORT, IDENTIFICATION IN A COMPLEX WITH HTLV-1 REX; RANBP3 AND RAN, INTERACTION WITH HTLV-1 REX AND RANBP3, MUTAGENESIS OF SER-191; VAL-284; ASP-334; ILE-337; THR-346; VAL-402; PRO-411; MET-412; PHE-414; ARG-474 AND HIS-481.Ref.25"PHAX and CRM1 are required sequentially to transport U3 snoRNA to nucleoli."_x005F_x005F_x000D_Boulon S., Verheggen C., Jady B.E., Girard C., Pescia C., Paul C., Ospina J.K., Kiss T., Matera A.G., Bordonne R., Bertrand E._x005F_x005F_x000D_Mol. Cell 16:777-787(2004) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN U3 SNORNA TRANSPORT, SUBCELLULAR LOCATION, RNA-BINDING.Ref.34"Nucleocytoplasmic shuttling of dysbindin-1, a schizophrenia-related protein, regulates synapsin I expression."_x005F_x005F_x000D_Fei E., Ma X., Zhu C., Xue T., Yan J., Xu Y., Zhou J., Wang G._x005F_x005F_x000D_J. Biol. Chem. 285:38630-38640(2010) [PubMed] [Europe PMC] [Abstract]Cited for: INTERACTION WITH DTNBP1, FUNCTION. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.117 ng/mL

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Exportin 5 (XPO5) in Tissue homogenates and other biological fluids.

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Exportin 5 (XPO5) in Tissue homogenates and other biological fluids.

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Exportin 5 (XPO5) in Tissue homogenates and other biological fluids.

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Exportin 5 (XPO5) in Tissue homogenates and other biological fluids.

Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Exportin 5 (XPO5) in samples from Tissue homogenates and other biological fluids. with no significant corss-reactivity with analogues from other species.