Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Valosin Containing Protein (VCP) in tissue homogenates, cell lysates and other biological fluids.

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Valosin Containing Protein (VCP) in tissue homogenates, cell lysates and other biological fluids.

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Valosin Containing Protein (VCP) in tissue homogenates, cell lysates and other biological fluids.

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Valosin Containing Protein (VCP) in tissue homogenates, cell lysates and other biological fluids.

Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Valosin Containing Protein (VCP) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Description: Recombinant Human Valosin Containing Protein expressed in: E.coli

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Valosin Containing Protein (VCP) in Tissue homogenates and other biological fluids.

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Valosin Containing Protein (VCP) in Tissue homogenates and other biological fluids.

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Valosin Containing Protein (VCP) in Tissue homogenates and other biological fluids.

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Valosin Containing Protein (VCP) in Tissue homogenates and other biological fluids.

Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Valosin Containing Protein (VCP) in samples from Tissue homogenates and other biological fluids. with no significant corss-reactivity with analogues from other species.

Description: A sandwich ELISA kit for detection of Valosin Containing Protein from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Description: A sandwich ELISA kit for detection of Valosin Containing Protein from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Description: Supplied as a 0.2 μm filtered solution of 50mM TrisHCl，pH8.0.

Description: Supplied as a 0.2 μm filtered solution of 50mM TrisHCl，pH8.0.

Description: Supplied as a 0.2 μm filtered solution of 50mM TrisHCl，pH8.0.

Description: Supplied as a 0.2 μm filtered solution of 50mM TrisHCl，pH8.0.

Description: A Rabbit polyclonal antibody against Human, Rat, Pig Valosin Containing Protein (VCP)

Description: A Rabbit polyclonal antibody against Human, Rat, Pig Valosin Containing Protein (VCP). This antibody is labeled with APC.

Description: A Rabbit polyclonal antibody against Human, Rat, Pig Valosin Containing Protein (VCP). This antibody is labeled with Biotin.

Description: A Rabbit polyclonal antibody against Human, Rat, Pig Valosin Containing Protein (VCP). This antibody is labeled with Cy3.

Description: A Rabbit polyclonal antibody against Human, Rat, Pig Valosin Containing Protein (VCP). This antibody is labeled with FITC.

Description: A Rabbit polyclonal antibody against Human, Rat, Pig Valosin Containing Protein (VCP). This antibody is labeled with HRP.

Description: A Rabbit polyclonal antibody against Human, Rat, Pig Valosin Containing Protein (VCP). This antibody is labeled with PE.

Description: A Rabbit polyclonal antibody against Human, Rat, Pig Valosin Containing Protein (VCP). This antibody is labeled with APC-Cy7.

Description: Valosin-Containing Protein (VCP) is a nuclear protein that belongs to the AAA ATPase family. VCP is a putative ATP-binding protein involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. It is necessary for the fragmentation of Golgi stacks during mitosis and their reassembly after mitosis. VCP has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation. VCP participates in the formation of the transitional endoplasmic reticulum (tER) and regulates E3 ubiquitin-protein ligase activity of RNF19A.

Description: VCPKMT Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 252 amino acids (1-229 a.a.) and having a molecular mass of 28.2kDa.

Description: Description of target: This gene encodes a member of the AAA ATPase family of proteins. The encoded protein plays a role in protein degradation, intracellular membrane fusion, DNA repair and replication, regulation of the cell cycle, and activation of the NF-kappa B pathway. This protein forms a homohexameric complex that interacts with a variety of cofactors and extracts ubiquitinated proteins from lipid membranes or protein complexes. Mutations in this gene cause IBMPFD (inclusion body myopathy with paget disease of bone and frontotemporal dementia), ALS (amyotrophic lateral sclerosis) and Charcot-Marie-Tooth disease in human patients.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.116 ng/mL

Description: Description of target: Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites. Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage. Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation. Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (PubMed:20104022).By similarity <p>Manually curated information which has been propagated from a related experimentally characterized protein.</p> <p><a href="/manual/evidences#ECO:0000250">More…</a></p> Manual assertion inferred from sequence similarity toiUniProtKB:P46462 (TERA_RAT)9 Publications <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.14"Physical and functional interaction between dorfin and valosin-containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders."_x005F_x005F_x000D_Ishigaki S., Hishikawa N., Niwa J., Iemura S., Natsume T., Hori S., Kakizuka A., Tanaka K., Sobue G._x005F_x005F_x000D_J. Biol. Chem. 279:51376-51385(2004) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH RNF19A, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-524.Ref.18"Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase."_x005F_x005F_x000D_Song B.L., Sever N., DeBose-Boyd R.A._x005F_x005F_x000D_Mol. Cell 19:829-840(2005) [PubMed] [Europe PMC] [Abstract]Cited for: INTERACTION WITH AMFR, FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-251 AND LYS-524.Ref.39"The AAA-ATPase p97 is essential for outer mitochondrial membrane protein turnover."_x005F_x005F_x000D_Xu S., Peng G., Wang Y., Fang S., Karbowski M._x005F_x005F_x000D_Mol. Biol. Cell 22:291-300(2011) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN OMM PROTEIN TURNOVER.Ref.44"The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks."_x005F_x005F_x000D_Meerang M., Ritz D., Paliwal S., Garajova Z., Bosshard M., Mailand N., Janscak P., Hubscher U., Meyer H., Ramadan K._x005F_x005F_x000D_Nat. Cell Biol. 13:1376-1382(2011) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.45"The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks."_x005F_x005F_x000D_Acs K., Luijsterburg M.S., Ackermann L., Salomons F.A., Hoppe T., Dantuma N.P._x005F_x005F_x000D_Nat. Struct. Mol. Biol. 18:1345-1350(2011) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH L3MBTL1.Ref.47"STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein."_x005F_x005F_x000D_Sato T., Sako Y., Sho M., Momohara M., Suico M.A., Shuto T., Nishitoh H., Okiyoneda T., Kokame K., Kaneko M., Taura M., Miyata M., Chosa K., Koga T., Morino-Koga S., Wada I., Kai H._x005F_x005F_x000D_Mol. Cell 47:99-110(2012) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN ERAD PATHWAY.Ref.50"DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage."_x005F_x005F_x000D_Davis E.J., Lachaud C., Appleton P., Macartney T.J., Nathke I., Rouse J._x005F_x005F_x000D_Nat. Struct. Mol. Biol. 19:1093-1100(2012) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH SPRTN.Ref.51"DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks."_x005F_x005F_x000D_Mosbech A., Gibbs-Seymour I., Kagias K., Thorslund T., Beli P., Povlsen L., Nielsen S.V., Smedegaard S., Sedgwick G., Lukas C., Hartmann-Petersen R., Lukas J., Choudhary C., Pocock R., Bekker-Jensen S., Mailand N._x005F_x005F_x000D_Nat. Struct. Mol. Biol. 19:1084-1092(2012) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH SPRTN.Ref.62"VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD."_x005F_x005F_x000D_Tresse E., Salomons F.A., Vesa J., Bott L.C., Kimonis V., Yao T.P., Dantuma N.P., Taylor J.P._x005F_x005F_x000D_Autophagy 6:217-227(2010) [PubMed] [Europe PMC] [Abstract]Cited for: CHARACTERIZATION OF VARIANTS IBMPFD1 HIS-155; SER-155 AND GLU-232, MUTAGENESIS OF GLU-305 AND GLU-578, FUNCTION. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.112 ng/mL

Description: Description of target: Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A. Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites. Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage. Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Required for cytoplasmic retrotranslocation of stressed/damaged mitochondrial outer-membrane proteins and their subsequent proteasomal degradation. Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy.;Species reactivity: Rat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.115 ng/mL

Description: A polyclonal antibody against VCP. Recognizes VCP from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/40000

Description: A polyclonal antibody against VCP. Recognizes VCP from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC

Description: A polyclonal antibody against VCP. Recognizes VCP from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200

Description: A polyclonal antibody against vcp. Recognizes vcp from Zebrafish. This antibody is Unconjugated. Tested in the following application: ELISA, WB; Recommended dilution: WB:1:500-1:5000

Description: Purified Polyclonal VCP antibody

Description: Purified Rabbit polyclonal VCP antibody

Description: Rabbit polyclonal VCP antibody

Description: Affinity purified rabbit polyclonal VCP antibody

Description: Rabbit polyclonal VCP antibody

Description: Affinity purified Rabbit polyclonal VCP antibody

Description: Quantitativesandwich ELISA kit for measuring Human Transitional endoplasmic reticulum ATPase (VCP) in samples from serum, plasma, tissue homogenates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Description: Quantitativesandwich ELISA kit for measuring Human Transitional endoplasmic reticulum ATPase(VCP) in samples from serum, plasma, tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Description: Description of target: ;Species reactivity: Human, Mouse, Rat;Application: ELISA;Assay info: Assay Type: Cell-Based
Subtype: None
Detection Method: Colorimetric 450 nm;Sensitivity:

Description: Kit to create frits in capillaries. Includes formamide, Kasil-1, Kasil-1624 and a cleaving tool.

Description: Probable serine carboxypeptidase CPVL, also known as Carboxypeptidase, vitellogenic-like, Vitellogenic carboxypeptidase-like protein, is a member of the peptidase S10 family. It is expressed in macrophages but not in other leukocytes. And specifically, it is abundantly expressed in heart and kidney, also expressed in spleen, leukocytes, and placenta. This enzyme may be involved in the digestion of phagocytosed particles in the lysosome, and also participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.

Description: Quantitative sandwich ELISA for measuring Human Transitional endoplasmic reticulum ATPase (VCP) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Description: Quantitative sandwich ELISA for measuring Human Transitional endoplasmic reticulum ATPase (VCP) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Description: Quantitative sandwich ELISA for measuring Human Transitional endoplasmic reticulum ATPase (VCP) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Description: Column packing kit for pressure cells. Includes: HPREG regulator, TBNG10 tubing, CAP-75 capillary, and STRB5X2 stir bar.

Description: A cloning plasmid for the VCP gene.

Description: A Rabbit Polyclonal antibody against VCP from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Description: A Rabbit Polyclonal antibody against VCP from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Description: Purified Rabbit polyclonal VCP antibody (Ser352)

Description: A polyclonal antibody for detection of VCP from Human, Mouse, Rat. This VCP antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human VCP around the non-phosphorylation site of S352

Description: A polyclonal antibody for detection of VCP from Human, Mouse, Rat. This VCP antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human VCP around the non-phosphorylation site of S352

Description: A polyclonal antibody for detection of VCP from Human, Mouse, Rat. This VCP antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human VCP around the non-phosphorylation site of S352

Description: A Monoclonal antibody against Human VCP. The antibodies are raised in Mouse. This antibody is applicable in IHC-P, FC, IF, WB

Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human VCP . This antibody is tested and proven to work in the following applications:

Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human VCP . This antibody is tested and proven to work in the following applications:

Description: Antibody raised against VCP

Description: Antibody raised against VCP

Description: VCP is a protein encoded by the VCP gene which is approximately 89,3 kDa. VCP is localised to the cytoplasm, endoplasmic reticulum and nucleus. It is involved in CDK-mediated phosphorylation and removal of Cdc6, the innate immune system, the cellular response to heat stress and the HIV life cycle. It is a structural protein that associates with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation. VCP is expressed in the nervous system, lung, liver, blood and skin. Mutations in the VCP gene result in inclusion body myopathy with early-onset Paget and Charcot-Marie-tooth disease type 2. STJ96231 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope specific immunogen. This polyclonal antibody detects endogenous levels of VCP protein.

Description: The protein encoded by this gene is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation.

Description: Mouse monoclonal to VCP

Description: Mouse monoclonal to VCP

Description: Mouse monoclonal to VCP

Description: Description of target: ;Species reactivity: Human: S352, Mouse: S352, Rat: S352;Application: ELISA;Assay info: Assay Type: Cell-Based
Subtype: Phospho
Detection Method: Colorimetric 450 nm;Sensitivity:

Description: Quantitative sandwich ELISA for measuring Rat Transitional endoplasmic reticulum ATPase (VCP) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Description: Quantitative sandwich ELISA for measuring Rat Transitional endoplasmic reticulum ATPase (VCP) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Description: Quantitative sandwich ELISA for measuring Rat Transitional endoplasmic reticulum ATPase (VCP) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Description: A polyclonal antibody against Phospho-VCP (S352). Recognizes Phospho-VCP (S352) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/5000

Description: A recombinant monoclonal antibody from rabbit against human VCP for WB, IHC,ELISA